Abstrak
Palatogenesis is the process of palate formation that develop via epithelium-mesenchymal interaction. The failure of this process causes cleft palate. Cleft palate commonly occurs in 1/15000 birth of worldwide. It is caused by genetic, environment, and also teratogenic component, which genetic is the most factor that causes cleft palate. Therefore, author aim to discuss about the effect of Fgf10 to the cleft palate. This study concluded that mutation in Fgf10 causes cleft palate as the result of epithelium-mesenchymal interaction error. It is because Fgf10 plays critical role to epithelium-mesenchymal interaction.
Keyword : Fgf10, cleft palate, epithelium-mesenchymal interaction, mutation
Referensi
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