Peran Interferon pada Pathogenesis Sindrom Sjogren

Abstract
Sjogren sindrom is a chronic autoimmune exocrinopathy distinguished by dry eyes and mouth. Its commonly affect 0,7% of the European population. Recent studies have reported on the association of interferon in the pathogenesis of Sjogren syndrom. Interferon is lead to salivary gland dysfunction by two mechanism, direct and indirect pathway. In the direct pathway, interferon may alter the structure and function of Tigth junction (TJ), and decrease Transepithelial Resistance (TER) of epithelial salivary gland cell. In the indirect pathway, Interferon could generate autoimmune system by interact with lymphocyte B and T. All these mechanism are lead to salivary gland dysfunction and dry mouth (xerostomia).

Keyword: Interferon, Sjogren syndrom, salivary gland cell, autoimmune, dry mouth.


Referensi
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